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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBX5
All Species:
22.73
Human Site:
Y502
Identified Species:
41.67
UniProt:
Q99593
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99593
NP_000183.2
518
57711
Y502
R
T
L
S
P
H
Q
Y
H
S
V
H
G
V
G
Chimpanzee
Pan troglodytes
XP_509400
518
57702
Y502
R
T
L
S
P
H
Q
Y
H
S
V
H
G
V
G
Rhesus Macaque
Macaca mulatta
XP_001111737
518
57694
Y502
R
T
L
S
P
H
Q
Y
H
S
V
H
G
V
G
Dog
Lupus familis
XP_548568
518
57556
Y502
R
T
L
S
P
H
Q
Y
H
S
V
H
G
V
A
Cat
Felis silvestris
Mouse
Mus musculus
P70326
518
57813
Y502
R
T
L
S
P
H
Q
Y
H
S
V
H
G
V
G
Rat
Rattus norvegicus
Q5I2P1
517
57726
Y501
R
T
L
S
P
H
Q
Y
H
S
V
H
G
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509097
536
59706
E518
Q
S
F
S
L
S
R
E
S
S
L
Q
Y
H
A
Chicken
Gallus gallus
Q9PWE8
521
58384
P502
G
V
P
R
T
L
S
P
H
Q
Y
H
S
V
H
Frog
Xenopus laevis
Q9W7C2
519
58062
Q502
P
R
T
I
S
P
H
Q
Y
H
S
V
H
G
V
Zebra Danio
Brachydanio rerio
Q9IAK8
492
55218
H477
T
L
S
P
H
Q
Y
H
T
V
H
S
V
S
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24432
972
102538
E832
G
L
G
G
G
V
V
E
N
G
P
R
S
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19691
423
46979
P408
K
E
Q
K
S
V
T
P
P
K
K
G
G
F
D
Sea Urchin
Strong. purpuratus
XP_797010
645
70075
S593
A
R
H
L
A
Q
Q
S
S
F
P
T
C
N
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
96.5
N.A.
96.1
95.7
N.A.
53.1
88.4
79.1
70
N.A.
22
N.A.
32.8
31.6
Protein Similarity:
100
99.8
99.8
98.2
N.A.
97.8
98
N.A.
63.6
94.4
85.7
78.9
N.A.
32.7
N.A.
48.2
43.8
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
13.3
20
0
0
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
40
20
6.6
6.6
N.A.
13.3
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
8
0
0
0
0
0
16
0
0
0
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
8
0
0
0
8
0
% F
% Gly:
16
0
8
8
8
0
0
0
0
8
0
8
54
8
39
% G
% His:
0
0
8
0
8
47
8
8
54
8
8
54
8
8
8
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
8
0
0
8
0
0
0
0
0
8
8
0
0
0
0
% K
% Leu:
0
16
47
8
8
8
0
0
0
0
8
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% N
% Pro:
8
0
8
8
47
8
0
16
8
0
16
0
0
0
0
% P
% Gln:
8
0
8
0
0
16
54
8
0
8
0
8
0
0
0
% Q
% Arg:
47
16
0
8
0
0
8
0
0
0
0
8
0
0
0
% R
% Ser:
0
8
8
54
16
8
8
8
16
54
8
8
16
8
16
% S
% Thr:
8
47
8
0
8
0
8
0
8
0
0
8
0
0
0
% T
% Val:
0
8
0
0
0
16
8
0
0
8
47
8
8
54
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
47
8
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _